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1996-03-04
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Document 0847
DOCN M9640847
TI Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid
malignancies in Italy and Spain.
DT 9604
AU Pastore C; Gloghini A; Volpe G; Nomdedeu J; Leonardo E; Mazza U; Saglio
G; Carbone A; Gaidano G; Laboratorio di Medicina e Oncologia Molecolare,
Dipartimento di; Scienze Biomediche e Oncologia Umana, Italy.
SO Br J Haematol. 1995 Dec;91(4):918-20. Unique Identifier : AIDSLINE
MED/96136090
AB In this study we have tested the distribution of Kaposi's sarcoma
herpesvirus (KSHV) DNA sequences throughout the spectrum of lymphoid
neoplasia in Italy and Spain. 180 cases of lymphoid malignancies
representative of the major histologic and immunophenotypic categories
of B- and T-cell tumours were analysed by means of a polymerase chain
reaction-based assay. KSHV sequences were consistently absent in all
categories of lymphoid malignancies studied, with the exception of a
subset of B-cell non-Hodgkin's lymphomas localizing in the pleural,
pericardial or peritoneal cavities, and fulfilling the diagnostic
criteria of body-cavity-based lymphoma. The selective and consistent
association of KSHV sequences with cases of body-cavity-based lymphoma
throughout the spectrum of lymphoid neoplasms suggests that KSHV may be
involved in the pathogenesis of this peculiar type of lymphoid
malignancy.
DE Base Sequence DNA Primers/GENETICS DNA, Viral/*ANALYSIS
Herpesviridae/*GENETICS Human HIV Infections/COMPLICATIONS/VIROLOGY
Italy Lymphoma/VIROLOGY Lymphoma, B-Cell/*VIROLOGY Lymphoma,
T-Cell/VIROLOGY Molecular Sequence Data Polymerase Chain Reaction
Sarcoma, Kaposi's/*VIROLOGY Spain Support, Non-U.S. Gov't JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).